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Radical/Polar Crossover: New Methodologies and Applications in Total Synthesis & Studies Towards a Synthesis of Asperterpenoid A
- Johnson, Lucas Kent
- Advisor(s): Vanderwal, Christopher D
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Abstract
This dissertation describes work completed in several areas of ongoing research in the Vanderwal Lab. Chapter 1 describes the family of natural products known as the abietane diterpenoids, the structural anomaly plebeianiol A, and our synthetic endeavor to elucidate the authentic structure of this natural product. Chapter 2 describes the development of a new radical/polar crossover annulation method using metal-hydride hydrogen atom transfer (MHAT) catalysis. Finally, Chapter 3 details our investigation into a synthetic route towards the sesterterpenoid natural product, asperterpenoid A.