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Basomedial amygdala mediates top-down control of anxiety and fear
- Adhikari, Avishek;
- Lerner, Talia N;
- Finkelstein, Joel;
- Pak, Sally;
- Jennings, Joshua H;
- Davidson, Thomas J;
- Ferenczi, Emily;
- Gunaydin, Lisa A;
- Mirzabekov, Julie J;
- Ye, Li;
- Kim, Sung-Yon;
- Lei, Anna;
- Deisseroth, Karl
Published Web Location
https://doi.org/10.1038/nature15698Abstract
Activation of the ventral medial prefrontal cortex–basomedial amygdala pathway is shown to suppress anxiety and fear-related freezing in mice, thus identifying the basomedial amygdala (and not intercalated cells, as posited by earlier models) as a novel target of top-down control.
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