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Conversion of amides to esters by the nickel-catalysed activation of amide C–N bonds
- Hie, Liana;
- Fine Nathel, Noah F;
- Shah, Tejas K;
- Baker, Emma L;
- Hong, Xin;
- Yang, Yun-Fang;
- Liu, Peng;
- Houk, KN;
- Garg, Neil K
Published Web Location
https://doi.org/10.1038/nature14615Abstract
Although enzymes are able to cleave amide bonds in nature, it is difficult to selectively break the carbon–nitrogen bond of an amide using synthetic chemistry; now the activation and cleavage of these bonds using nickel catalysts is used to convert amides to esters.
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