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Catalase Involved in Oxidative Cyclization of the Tetracyclic Ergoline of Fungal Ergot Alkaloids
- Yao, Yongpeng;
- An, Chunyan;
- Evans, Declan;
- Liu, Weiwei;
- Wang, Wei;
- Wei, Guangzheng;
- Ding, Ning;
- Houk, KN;
- Gao, Shu-Shan
Published Web Location
https://doi.org/10.1021/jacs.9b10217Abstract
A dedicated enzyme for the formation of the central C ring in the tetracyclic ergoline of clinically important ergot alkaloids has never been found. Herein, we report a dual role catalase (EasC), unexpectedly using O2 as the oxidant, that catalyzes the oxidative cyclization of the central C ring from a 1,3-diene intermediate. Our study showcases how nature evolves the common catalase for enantioselective C-C bond construction of complex polycyclic scaffolds.
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