UCLA

PURPOSE: To implement an accelerated MR-acquisition method allowing to map relaxation and absolute concentration of sodium within skeletal muscles at 3T. METHODS: A fast-UTE-2D density-weighted concentric-ring-trajectory ²³ Na-MRSI technique was used to acquire 64 time points of FID with a spectral bandwidth of 312.5 Hz with an in-plane resolution of 2.5 × 2.5 mm² in ~15 min. The fast-relaxing ²³ Na signal was localized with a single-shot, inversion-recovery-based, non-echo (SIRENE) outer volume suppression (OVS) method. The sequence was verified using simulation and phantom studies before implementing it in human calf muscles. To evaluate the 2D-SIRENE-MRSI (UTE = 0.55 ms) imaging performance, it was compared to a 3D-MRI (UTE = 0.3 ms) sequence. Both data sets were acquired within 2 same-day sessions to assess repeatability. The values were fitted voxel-by-voxel using a biexponential model for the 2D-MRSI data. Finally, intra-subject coefficients of variation (CV) were estimated. RESULTS: The MRSI-FID data allowed us to map the fast and slow components of in the calf muscles. The spatial distributions of ²³ Na concentration for both MRSI and 3D-MRI acquisitions were significantly correlated (P < .001). The test-retest analysis rendered high repeatability for MRSI with a CV of 5%. The mean in muscles was 0.7 ± 0.1 ms (contribution fraction = 37%), whereas was 13.2 ± 0.2 ms (63%). The mean absolute muscle ²³ Na concentration calculated from the -corrected data was 28.6 ± 3.3 mM. CONCLUSION: The proposed MRSI technique is a reliable technique to map sodium's absolute concentration and within a clinically acceptable scan time at 3T.