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Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
- Chen, Zhengshan;
- Shojaee, Seyedmehdi;
- Buchner, Maike;
- Geng, Huimin;
- Lee, Jae Woong;
- Klemm, Lars;
- Titz, Björn;
- Graeber, Thomas G;
- Park, Eugene;
- Tan, Ying Xim;
- Satterthwaite, Anne;
- Paietta, Elisabeth;
- Hunger, Stephen P;
- Willman, Cheryl L;
- Melnick, Ari;
- Loh, Mignon L;
- Jung, Jae U;
- Coligan, John E;
- Bolland, Silvia;
- Mak, Tak W;
- Limnander, Andre;
- Jumaa, Hassan;
- Reth, Michael;
- Weiss, Arthur;
- Lowell, Clifford A;
- Müschen, Markus
Published Web Location
https://doi.org/10.1038/nature14231Abstract
This study shows that, despite malignant transformation, autoimmune checkpoints are still functional in B-cell leukaemia, with targeted activation of these checkpoints effectively killing patient-derived B-cell leukaemia in a transplant model; the results represent a novel strategy to overcome drug resistance in leukaemia patients.
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