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Open Access Publications from the University of California

Spiny keratoderma

  • Author(s): Nagler, Arielle
  • Boyd, Kevin P
  • Patel, Rishi R
  • Lee, Hyun-soo
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license

We present a case of a 48-year-old man with an approximately 30-year history of spiny projections on the palms, which were histopathologically consistent with spiny keratoderma. Spiny keratoderma is a rare entity of unknown etiology that has been described with both hereditary and acquired variants. The hereditary form, which is most likely the diagnosis in our patient, manifests at a younger age and is benign. The acquired variant, which presents in older adults, has been associated with a variety of systemic diseases and malignant conditions. In patients suspected of having acquired spiny keratoderma, an evaluation for malignant conditions may be warranted.

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