UCLA

Background

To assess the long-term biological coefficient of variation within individuals (CV_I) and between individuals (CV_G), effect of aging and cholesterol lowering drugs on blood levels of lipids in HIV-1-infected and -uninfected men.

Methods

Bloods were analyzed every six months over 17 years for total cholesterol (TC), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) in 140 HIV-uninfected (38-66 years old) and 90 HIV-treated infected (48-64 years old) white Caucasian men to examine CV_I, CV_G, and the effect of cholesterol lowering drugs (CLDs) on lipid levels, and estimated changes per year of biomarkers.

Results

With exception of HDL-C, the long term CV_I compared with CV_G were higher for serum levels of TC, TGs, and LDL-C in both HIV-1 infected and uninfected men not taking CLDs. Excluding results of TGs in HIV positive men, the CV_I compared with CV_G were lower for serum levels of TC, HDL-C, and LDL-C in both groups not taking CLDs. There were significant (p < 0.05) differences in the median serum values of lipid biomarkers among 77 HIV negative men taking and 63 not taking CLDs. Also, with exception of HDL, there were significant (p < 0.05) differences in the median values of TC, TGs and LDL-C among 28 HIV positive men taking or not taking CLDs.

Conclusion

Long term CV_I and CV_G of biomarkers will be useful for monitoring antiviral therapy side effects on lipid profiles in HIV-infected men. CV_I of HIV-infected men for TC, TGs, HDL, LDL were higher significantly than CV_I of HIV-uninfected men. Interestingly the long term CV_I were higher than CV_G for the men, who were on CLDs compared to men not on CLDs. The long-term pattern of CV_I and CV_G of lipid markers in both HIV-infected and uninfected men on CLDs differed from their short-term pattern.