UC Irvine

Hyperkalemia and hypokalemia are extremely common electrolyte imbalances resulting from abnormal excretion or intracellular shifts. These conditions are frequently observed in hospitalized patients, particularly those with kidney diseases and individuals taking specific medications. Severe, life-threatening arrhythmias can develop suddenly without warning or symptoms. Continuous monitoring for potassium imbalances is critical for maintaining physiological stability and preventing severe complications, especially in at-risk patients. This research focuses on developing an optical potassium sensor with a fast response time and reversibility for continuous monitoring. It explores the process of developing a sensitive potassium sensor film using drop cast and spin coating techniques. The absorbance and fluorescence responses were analyzed through plate reader experiments, and a ratiometric fluorescence signal was demonstrated using a miniature benchtop spectrometer. To further advance the sensor's functionality, various optoelectronic components were designed and tested for potential integration into a thin, flexible circuit.