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Dermatology Online Journal

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Pitted keratolysis: successful management with mupirocin 2% ointment monotherapy


Background: Pitted keratolysis is a benign dermatosis that occurs on plantar skin.

Purpose: We describe a man with pitted keratolysis that was successfully treated with mupirocin 2% ointment monotherapy.

Methods and Materials: We reviewed PubMed for the following terms: mupirocin, ointment, pitted keratolysis, treatment. We also reviewed papers containing these terms and their references.

Results: Complete resolution of pitted keratolysis occurred following monotherapy with twice daily application of mupirocin 2% ointment for a duration of three weeks. There was no recurrence at a follow-up visit eight weeks later.

Conclusions: Several topical and oral treatments are available to successfully manage pitted keratolysis. Our patient confirms previous reports of pitted keratolysis resolving with mupirocin 2% ointment treatment. Monotherapy with mupirocin 2% ointment should be considered as a primary treatment alternative for pitted keratolysis.

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