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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
- Bulik-Sullivan, Brendan K;
- Loh, Po-Ru;
- Finucane, Hilary K;
- Ripke, Stephan;
- Yang, Jian;
- Patterson, Nick;
- Daly, Mark J;
- Price, Alkes L;
- Neale, Benjamin M
Published Web Location
https://doi.org/10.1038/ng.3211Abstract
Benjamin Neale and colleagues report the LD Score regression method, used to distinguish the relative contributions of confounding bias and polygenicity to inflated test statistics in GWAS. They apply their method to summary statistics from GWAS for over 30 phenotypes, confirm that polygenicity accounts for the majority of inflation in test statistics and demonstrate use of this method as a correction factor.
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