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Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice
- Devkota, Suzanne;
- Wang, Yunwei;
- Musch, Mark W;
- Leone, Vanessa;
- Fehlner-Peach, Hannah;
- Nadimpalli, Anuradha;
- Antonopoulos, Dionysios A;
- Jabri, Bana;
- Chang, Eugene B
Published Web Location
https://doi.org/10.1038/nature11225Abstract
Consumption of a diet high in milk-derived fat is shown to increase the abundance of sulphite-reducing bacteria by altering bile composition, leading to inflammation and colitis in genetically susceptible mice.
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