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Open Access Publications from the University of California

Surgical restabilization following ACL rupture in mice slows the progression of post-traumatic osteoarthritis

Abstract

Post-traumatic osteoarthritis (PTOA) occursfollowing an injury such as Anterior CruciateLigament (ACL) rupture. Clinically, ACLreconstruction surgery is performedfollowing injury. However, it is unclear howeffective knee restabilization is in slowingPTOA progression. This study hypothesized that knee restabilization would slow the progression of PTOA, but the procedure itself would have some mild PTOA-like joint degeneration.