UCLA

Co-deletion of 1p/19q is a hallmark of oligodendroglioma and predicts better survival. However, little is understood about its metabolic characteristics. In this study, we aimed to explore the extracellular acidity of WHO grade II and III gliomas associated with 1p/19q co-deletion. We included 76 glioma patients who received amine chemical exchange saturation transfer (CEST) imaging at 3 T. Magnetic transfer ratio asymmetry (MTR_asym) at 3.0 ppm was used as the pH-sensitive CEST biomarker, with higher MTR_asym indicating lower pH. To control for the confounder factors, T₂ relaxometry and L-6-¹⁸F-fluoro-3,4-dihydroxyphenylalnine (¹⁸F-FDOPA) PET data were collected in a subset of patients. We found a significantly lower MTR_asym in 1p/19q co-deleted gliomas (co-deleted, 1.17% ± 0.32%; non-co-deleted, 1.72% ± 0.41%, P = 1.13 × 10^-7), while FDOPA (P = 0.92) and T₂ (P = 0.61) were not significantly affected. Receiver operating characteristic analysis confirmed that MTR_asym could discriminate co-deletion status with an area under the curve of 0.85. In analysis of covariance, 1p/19q co-deletion status was the only significant contributor to the variability in MTR_asym when controlling for age and FDOPA (P = 2.91 × 10^-3) or T₂ (P = 8.03 × 10^-6). In conclusion, 1p/19q co-deleted gliomas were less acidic, which may be related to better prognosis. Amine CEST-MRI may serve as a non-invasive biomarker for identifying 1p/19q co-deletion status.