Skip to main content
eScholarship
Open Access Publications from the University of California

Nutrition Bytes

Nutrition Bytes bannerUCLA

Probiotics, beneficial bacteria, and inflammatory bowel disease – What do we actually know?

  • Author(s): Takatori, Nanae
  • et al.
Abstract

Despite the common use of probiotics in bowel disorders, little is known about the mechanisms by which probiotics produce a beneficial effect. The clear identification of antigens and the immune cells that they interact with still remain to be discovered. The recent discovery of the anti-inflammatory effects of Bacteriodes fragilis has revealed a new concept of polysaccharide antigen presentation on antigen presenting cells. It has been found that polysaccharide A (PSA), produced by B. fragilis, interacts with antigen presenting cells and T-cells to modulate a potent anti-inflammatory response. The aim of this paper is to briefly summarize the mechanisms by which a specific probiotic organism, Lactobacilus rhamnosus GG, and the bacterium B. fragilis exert their beneficial effects while elucidating areas that need more study.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View