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Enzymatic cis-Decalin Formation in Natural Product Biosynthesis
- Ohashi, Masao;
- Tan, Dan;
- Lu, Jiayan;
- Jamieson, Cooper S;
- Kanayama, Daiki;
- Zhou, Jiahai;
- Houk, KN;
- Tang, Yi
Published Web Location
https://doi.org/10.1021/jacs.2c12854Abstract
Stereoselective synthesis of cis-decalin structures using [4 + 2] cycloaddition is challenging. We explored the biosynthetic pathway of the fungal natural product fischerin (1) to identify a new pericyclase FinI that can catalyze such a reaction. The cocrystal structure of FinI, a predicted O-methyltransferase, with the product and SAM provides insight into cis-decalin formation in nature.
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