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An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery
- Wang, Bo;
- Wen, Ximiao;
- Cao, Yan;
- Huang, Shan;
- Lam, Hoa A;
- Liu, Tingyi Leo;
- Chung, Pei-Shan;
- Monbouquette, Harold G;
- Chiou, Pei-Yu;
- Maidment, Nigel T
Published Web Location
https://doi.org/10.1039/d0lc00021cAbstract
A multifunctional chemical neural probe fabrication process exploiting PDMS thin-film transfer to incorporate a microfluidic channel onto a silicon-based microelectrode array (MEA) platform, and enzyme microstamping to provide multi-analyte detection is described. The Si/PDMS hybrid chemtrode, modified with a nano-based on-probe IrOx reference electrode, was validated in brain phantoms and in rat brain.
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