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Open Access Publications from the University of California

Targeted Molecular Imaging of Cancer Cells Using MS2-Based129Xe NMR

  • Author(s): Jeong, K
  • Netirojjanakul, C
  • Munch, HK
  • Sun, J
  • Finbloom, JA
  • Wemmer, DE
  • Pines, A
  • Francis, MB
  • et al.

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© 2016 American Chemical Society. We have synthesized targeted, selective, and highly sensitive129Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized129Xe NMR signal contrast and hyper-CEST129Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized129Xe NMR nanoscale biosensor for future applications in cancer detection in vivo.

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