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Targeted Molecular Imaging of Cancer Cells Using MS2-Based (129)Xe NMR.

  • Author(s): Jeong, Keunhong
  • Netirojjanakul, Chawita
  • Munch, Henrik K
  • Sun, Jinny
  • Finbloom, Joel A
  • Wemmer, David E
  • Pines, Alexander
  • Francis, Matthew B
  • et al.

Published Web Location

http://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.6b00275
No data is associated with this publication.
Abstract

We have synthesized targeted, selective, and highly sensitive (129)Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized (129)Xe NMR signal contrast and hyper-CEST (129)Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized (129)Xe NMR nanoscale biosensor for future applications in cancer detection in vivo.

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