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Open Access Publications from the University of California

Risk factors for Candida urinary tract infections in dogs and cats.

  • Author(s): Reagan, Krystle L
  • Dear, Jonathan D
  • Kass, Philip H
  • Sykes, Jane E
  • et al.

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BACKGROUND:Candida urinary tract infections occur in both dogs in cats but there is limited data about risk factors. OBJECTIVE:To identify risk factors for candiduria in dogs in cats. ANIMALS:Eighteen dogs and 8 cats with candiduria. METHODS:A retrospective case-control study, using univariate exact logistic regression. Medical records were searched for a diagnosis of Candida and animals with culture-confirmed candiduria were enrolled. Controls had bacterial cystitis (dogs and cats) or cutaneous Malassezia infection (dogs only). RESULTS:Administration of antibacterial drugs in the 30 days before diagnosis was associated with candiduria in dogs compared to controls with bacterial cystitis (OR 14.5; 95% CI 3.1-66.9) or with Malassezia infection (OR 26.4; 95% CI 3.4-206.7). Antecedent antibacterial drug administration was associated with candiduria in cats (OR 15.7; 95% CI 1.9-132.3). Immunosuppression was associated with candiduria in dogs when compared to controls with Malassezia infection (OR 4.2, 95% CI 1.4-12.8), but not significantly when compared to dogs with bacterial cystitis (OR 2.7, 95% CI 0.9-8.0). Lower urinary tract diseases other than infection were associated with candiduria in cats (OR 6.7, 95% CI 1.6-27.9), but not significantly in dogs (OR 2.5, 95% CI 0.7-8.7). Neither diabetes mellitus nor history of hospitalization was significantly associated with candiduria in either species. CONCLUSIONS AND CLINICAL IMPORTANCE:The recent administration of antibacterial drug therapy is a potential risk factor for development of candiduria in dogs and cats. Judicious use of antibacterial drugs might help to prevent candiduria.

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