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Spatial distribution of MRI-Determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease.

  • Author(s): Bonekamp, Susanne
  • Bonekamp, Susanne
  • Tang, An
  • Mashhood, Arian
  • Wolfson, Tanya
  • Changchien, Christopher
  • Middleton, Michael S
  • Clark, Lisa
  • Gamst, Anthony
  • Loomba, Rohit
  • Sirlin, Claude B
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083476/pdf/nihms514287.pdf
No data is associated with this publication.
Abstract

PURPOSE:To describe the spatial distribution of liver fat,using MRI-estimated proton density fat fraction (PDFF), in adults with nonalcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS:This Investigational Review Board-approved, Health Insurance Portability and Accountability Act-compliant study prospectively enrolled 50 adults (30 women, 20 men) with biopsy-proven NAFLD. Hepatic PDFF was measured by low-flip-angle multiecho spoiled gradient-recalled-echo MRI at 3 Tesla. Three nonoverlapping regions of interest were placed within each liver segment. Statistical analyses included Pearson's correlation, multivariable linear regression, and permutation-based paired tests. RESULTS:The study population's mean whole-liver PDFF was 16.1% (range: 1.6–39.6%). The mean whole-liver PDFF variability was 1.9% (range: 0.7–4.5%). Higher variability was associated with higher PDFF (r=0.34;P=0.0156). The mean PDFF was significantly higher in the right lobe than the left (16.5% versus 15.3%, P=0.0028). The mean PDFF variability was higher in the left lobe than the right (1.86% versus 1.28%; P<0.0001). Segment II had the lowest mean segmental PDFF (14.8%);segment VIII had the highest (16.7%). Segments V(0.71%) and VI (0.70%) had the lowest mean segmental PDFF variability; segment II had the highest (1.32%). CONCLUSION:IN adult NAFLD there are small but significant differences in fat content.

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