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Directional dominance on stature and cognition in diverse human populations
- Joshi, Peter K;
- Esko, Tonu;
- Mattsson, Hannele;
- Eklund, Niina;
- Gandin, Ilaria;
- Nutile, Teresa;
- Jackson, Anne U;
- Schurmann, Claudia;
- Smith, Albert V;
- Zhang, Weihua;
- Okada, Yukinori;
- Stančáková, Alena;
- Faul, Jessica D;
- Zhao, Wei;
- Bartz, Traci M;
- Concas, Maria Pina;
- Franceschini, Nora;
- Enroth, Stefan;
- Vitart, Veronique;
- Trompet, Stella;
- Guo, Xiuqing;
- Chasman, Daniel I;
- O'Connel, Jeffrey R;
- Corre, Tanguy;
- Nongmaithem, Suraj S;
- Chen, Yuning;
- Mangino, Massimo;
- Ruggiero, Daniela;
- Traglia, Michela;
- Farmaki, Aliki-Eleni;
- Kacprowski, Tim;
- Bjonnes, Andrew;
- van der Spek, Ashley;
- Wu, Ying;
- Giri, Anil K;
- Yanek, Lisa R;
- Wang, Lihua;
- Hofer, Edith;
- Rietveld, Cornelius A;
- McLeod, Olga;
- Cornelis, Marilyn C;
- Pattaro, Cristian;
- Verweij, Niek;
- Baumbach, Clemens;
- Abdellaoui, Abdel;
- Warren, Helen R;
- Vuckovic, Dragana;
- Mei, Hao;
- Bouchard, Claude;
- Perry, John RB;
- Cappellani, Stefania;
- Mirza, Saira S;
- Benton, Miles C;
- Broeckel, Ulrich;
- Medland, Sarah E;
- Lind, Penelope A;
- Malerba, Giovanni;
- Drong, Alexander;
- Yengo, Loic;
- Bielak, Lawrence F;
- Zhi, Degui;
- van der Most, Peter J;
- Shriner, Daniel;
- Mägi, Reedik;
- Hemani, Gibran;
- Karaderi, Tugce;
- Wang, Zhaoming;
- Liu, Tian;
- Demuth, Ilja;
- Zhao, Jing Hua;
- Meng, Weihua;
- Lataniotis, Lazaros;
- van der Laan, Sander W;
- Bradfield, Jonathan P;
- Wood, Andrew R;
- Bonnefond, Amelie;
- Ahluwalia, Tarunveer S;
- Hall, Leanne M;
- Salvi, Erika;
- Yazar, Seyhan;
- Carstensen, Lisbeth;
- de Haan, Hugoline G;
- Abney, Mark;
- Afzal, Uzma;
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- Baumeister, Sebastian E;
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- Chakravarti, Aravinda;
- Chan, Yingleong;
- Chanock, Stephen J;
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- Chen, Y-D Ida;
- Collins, Francis S;
- Connell, John;
- Correa, Adolfo;
- Cupples, L Adrienne;
- Smith, George Davey;
- Davies, Gail;
- Dörr, Marcus;
- Ehret, Georg;
- Ellis, Stephen B;
- Feenstra, Bjarke;
- Feitosa, Mary F;
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- Friedrich, Nele;
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- Scotland, Generation;
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- Masciullo, Corrado;
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- Menni, Cristina;
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- Milani, Lili;
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- Montgomery, Grant W;
- Morrison, Alanna;
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- Nelis, Mari;
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- Ogunniyi, Adesola;
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- Rose, Richard;
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- Griffiths, Lyn R;
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- Pirastu, Nicola;
- Kaprio, Jaakko;
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- Girotto, Giorgia;
- Caulfield, Mark J;
- Raitakari, Olli;
- Boomsma, Dorret I;
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- van der Harst, Pim;
- Hicks, Andrew A;
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- Knekt, Paul;
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- Magnusson, Patrik KE;
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- Schmidt, Reinhold;
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- Metspalu, Andres;
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Published Web Location
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516141/No data is associated with this publication.
Abstract
An analysis of 16 health-related quantitative traits in approximately 350,000 individuals reveals statistically significant associations between genome-wide homozygosity and four complex traits (height, lung function, cognitive ability and educational attainment); in each case increased homozygosity associates with a decreased trait value, but no evidence was seen of an influence on blood pressure, cholesterol, or ten other cardio-metabolic traits.
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