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A Fresh Approach to Targeting Aging Cells: CAR-T Cells Enhance Senolytic Specificity
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https://doi.org/10.1016/j.stem.2020.07.010Abstract
Senescence is a critical factor in several diseases, yet senolytic therapies targeting senescent cells remain hindered by lack of specificity. In the June issue of Nature, Amor et al. (2020) develop chimeric antigen receptor (CAR)-T cells targeting uPAR, a novel senescent-cell marker, to treat liver adenocarcinoma and liver fibrosis.
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