• Isotretinoin (13-cis-retinoic acid) is a retinoid or vitamin A derivative widely used to treat severe acne vulgaris.
• Decreases sebum production and prevents comedo formation.
• Isotretinoin use is associated with a variety of toxicities: developmental, cutaneous, musculoskeletal, etc.
• including hyperosteosis and premature epiphyseal closure at high doses.
• No studies examining pediatric growth in patients treated with isotretinoin at doses appropriate for severe, recalcitrant acne vulgaris treatment.
