Institute for Clinical and Translational Science
Antibody-dependent cell-mediated virus inhibition (ADCVI) antibody activity does not correlate with risk of HIV-1 superinfection
- Author(s): FORTHAL, Donald N.
- LANDUCCI, Gary
- CHOHAN, Bhavna
- RICHARDSON, Barbra A.
- MCCLELLAND, R. Scott
- JAOKO, Walter
- BLISH, Catherine
- OVERBAUGH, Julie
- et al.
Published Web Locationhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625514/pdf/nihms-444895.pdf
Previous studies of HIV-infected women with high risk behavior have indicated that neither neutralizing antibody nor cellular immunity elicited by an initial HIV-1 infection is associated with protection against superinfection with a different HIV-1 strain. Here, we measured antibody-dependent cell-mediated virus inhibition (ADCVI) antibody activity in the plasma of 12 superinfected cases and 36 singly infected matched controls against 2 heterologous viruses. We found no association between plasma ADCVI activity and superinfection status. ADCVI antibody activity against heterologous virus elicited by the original infection may not contribute to preventing a superinfecting HIV-1.