Skip to main content
eScholarship
Open Access Publications from the University of California

Calcium imaging of sleep-wake related neuronal activity in the dorsal pons

  • Author(s): Cox, J
  • Pinto, L
  • Dan, Y
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773416/
No data is associated with this publication.
Abstract

The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca 2+ imaging in and near the laterodorsal tegmental nucleus, we found that many glutamatergic neurons are maximally active during REM sleep (REM-max), while the majority of GABAergic neurons are maximally active during wakefulness (wake-max). Furthermore, the activity of glutamatergic neurons exhibits a medio-lateral spatial gradient, with medially located neurons more selectively active during REM sleep.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item