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STING is a direct innate immune sensor of cyclic di-GMP
- Burdette, Dara L;
- Monroe, Kathryn M;
- Sotelo-Troha, Katia;
- Iwig, Jeff S;
- Eckert, Barbara;
- Hyodo, Mamoru;
- Hayakawa, Yoshihiro;
- Vance, Russell E
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203314/No data is associated with this publication.
Abstract
Bacterial metabolites recognized by STINGCyclic dinucleotides, used as signalling molecules in bacteria but not in mammalian cells, are recognized by the mammalian innate immune system, triggering the production of type I interferon. Here the mammalian protein STING (stimulator of IFN genes) is identified as the direct molecular sensor for cyclic diguanylate monophosphate and other cyclic dinucleotides. Previously, STING was thought to act solely as a downstream signalling adaptor. Cyclic dinucleotides are potent immunostimulants, and may prove useful therapeutically.
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