Trafficking ofNMDAreceptors during status epilepticus: Therapeutic implications
- Author(s): Wasterlain, CG
- Naylor, DE
- Liu, H
- Niquet, J
- Baldwin, R
- et al.
Published Web Locationhttps://doi.org/10.1111/epi.12285
We used two models of status epilepticus (SE) to study trafficking of N-methyl-D-aspartate (NMDA) receptors. SE is associated with increased surface expression of NR1 subunits of NMDA receptors, and with an increase of NMDA synaptic and extrasynaptic currents suggesting an increase in number of functional NMDA receptors on dentate granule cells. The therapeutic implications of these results are discussed. © 2013 International League Against Epilepsy.
Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.