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Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials

  • Author(s): Noureddin, M
  • Lam, J
  • Peterson, MR
  • Middleton, M
  • Hamilton, G
  • Le, TA
  • Bettencourt, R
  • Changchien, C
  • Brenner, DA
  • Sirlin, C
  • Loomba, R
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819962/pdf/nihms764249.pdf
No data is associated with this publication.
Abstract

The magnetic resonance imaging-estimated proton density fat fraction (MRI-PDFF) is a novel imaging-based biomarker that allows fat mapping of the entire liver, whereas the magnetic resonance spectroscopy-measured proton density fat fraction (MRS-PDFF) provides a biochemical measure of liver fat in small regions of interest. Cross-sectional studies have shown that MRI-PDFF correlates with MRS-PDFF. The aim of this study was to show the utility of MRI-PDFF in assessing quantitative changes in liver fat through a three-way comparison of MRI-PDFF and MRS-PDFF with the liver histology-determined steatosis grade at two time points in patients with nonalcoholic fatty liver disease (NAFLD). Fifty patients with biopsy-proven NAFLD who participated in a randomized trial underwent a paired evaluation with liver biopsy, MRI-PDFF, and MRS-PDFF at the baseline and 24 weeks. The mean age and body mass index were 47.8±11.7 years and 30.7±6.5 kg/m2, respectively. MRI-PDFF showed a robust correlation with MRS-PDFF both at week 0 and at week 24 (r=0.98, P<0.0001 for both). Cross-sectionally, MRI-PDFF and MRS-PDFF increased with increases in the histology-determined steatosis grade both at week 0 and at week 24 (P<0.05 for all). Longitudinally, patients who had a decrease (≥1%) or increase (≥1%) in MRI-PDFF (confirmed by MRS-PDFF) showed a parallel decrease or increase in their body weight and serum alanine aminotransferase and aspartate aminotransferase levels at week 24 (P<0.05). This small increase or decrease in liver fat could not be quantified with histology. Conclusion: In this longitudinal study, MRI-PDFF correlated well with MRS-PDFF and was more sensitive than the histology-determined steatosis grade in quantifying increases or decreases in the liver fat content. Therefore, it could be used to quantify changes in liver fat in future clinical trials. © 2013 by the American Association for the Study of Liver Diseases.

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