Skip to main content
eScholarship
Open Access Publications from the University of California

The role of hypothalamus-pituitary-adrenal (HPA)-like axis in inflammatory pilosebaceous disorders

  • Author(s): Saric-Bosanac, Suzana
  • Clark, Ashley K
  • Sivamani, Raja K
  • Shi, Vivian Y
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license
Abstract

Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity. The pilosebaceous unit is a site for production and metabolism of a number of steroid hormones, including stress and sex hormones. This is an overview of the important role that the cutaneous HPA-like-axis plays in the pathogenesis and treatment of inflammatory pilosebaceous disorders, including acne, rosacea, seborrheic dermatitis, and hidradenitis suppurativa.

Main Content
Current View