Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing.
- Author(s): Mo, Alexander H
- Landon, Preston B
- Gomez, Karla Santacruz
- Kang, Heemin
- Lee, Joon
- Zhang, Chen
- Janetanakit, Woraphong
- Sant, Vrinda
- Lu, Tianyu
- Colburn, David A
- Akkiraju, Siddhartha
- Dossou, Samuel
- Cao, Yue
- Lee, Kuo-Fen
- Varghese, Shyni
- Glinsky, Gennadi
- Lal, Ratnesh
- et al.
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295298/Abstract
Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro.
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