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Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing.

  • Author(s): Mo, Alexander H
  • Landon, Preston B
  • Gomez, Karla Santacruz
  • Kang, Heemin
  • Lee, Joon
  • Zhang, Chen
  • Janetanakit, Woraphong
  • Sant, Vrinda
  • Lu, Tianyu
  • Colburn, David A
  • Akkiraju, Siddhartha
  • Dossou, Samuel
  • Cao, Yue
  • Lee, Kuo-Fen
  • Varghese, Shyni
  • Glinsky, Gennadi
  • Lal, Ratnesh
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295298/
No data is associated with this publication.
Abstract

Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro.

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