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Intrauterine Candida albicans infection elicits severe inflammation in fetal sheep.
- Author(s): Payne, Matthew S;
- Kemp, Matthew W;
- Kallapur, Suhas G;
- Kannan, Paranthaman Senthamarai;
- Saito, Masatoshi;
- Miura, Yuichiro;
- Newnham, John P;
- Stock, Sarah;
- Ireland, Demelza J;
- Kramer, Boris W;
- Jobe, Alan H
- et al.
Published Web Locationhttps://doi.org/10.1038/pr.2014.35
BackgroundPreventing preterm birth and subsequent adverse neonatal sequelae is among the greatest clinical challenges of our time. Recent studies suggest a role for Candida spp. in preterm birth and fetal injury, as a result of their colonization of either the vagina and/or the amniotic cavity. We hypothesized that intraamniotic Candida albicans would cause a vigorous, acute fetal inflammatory response.
MethodsSheep carrying singleton pregnancies received single intraamniotic injections of either saline (control) or 10(7) colony-forming units C. albicans 1 or 2 d prior to surgical delivery and euthanasia at 124 ± 2 d gestation.
ResultsColonization of the amniotic cavity by C. albicans resulted in a modest inflammatory response at 1 d and florid inflammation at 2 d, characterized by fetal thrombocytopenia, lymphopenia, and significant increases of inflammatory cytokines/chemokines in the fetal membranes skin, lung, and the amniotic fluid.
ConclusionAcute colonization of the amniotic cavity by C. albicans causes severe intrauterine inflammation and fetal injury. C. albicans is a potent fetal pathogen that can contribute to adverse pregnancy outcomes.
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