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Two hydrophobic residues can determine the specificity of Mitogen-activated protein Kinase docking interactions

  • Author(s): Jane Bardwell, A
  • Bardwell, L
  • et al.

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Background: MAPK cascade proteins bind to each other selectively via docking interactions. Results: The high selectivity of JNK family MAPKs for cognate binding partners is controlled by two key hydrophobic residues in the docking site. Conclusion: This contrasts with other proposed models of docking specificity. Significance: This has implications for drug design and for the evolution of signaling specificity.

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