Skip to main content
eScholarship
Open Access Publications from the University of California

Two hydrophobic residues can determine the specificity of Mitogen-activated protein Kinase docking interactions

  • Author(s): Jane Bardwell, A
  • Bardwell, L
  • et al.

Published Web Location

http://www.jbc.org/content/290/44/26661.long
No data is associated with this publication.
Abstract

© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Background: MAPK cascade proteins bind to each other selectively via docking interactions. Results: The high selectivity of JNK family MAPKs for cognate binding partners is controlled by two key hydrophobic residues in the docking site. Conclusion: This contrasts with other proposed models of docking specificity. Significance: This has implications for drug design and for the evolution of signaling specificity.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item