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Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
- Chen, Janice S;
- Dagdas, Yavuz S;
- Kleinstiver, Benjamin P;
- Welch, Moira M;
- Sousa, Alexander A;
- Harrington, Lucas B;
- Sternberg, Samuel H;
- Joung, J Keith;
- Yildiz, Ahmet;
- Doudna, Jennifer A
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918688/No data is associated with this publication.
Abstract
A new engineered version of SpCas9, called HypaCas9, displays enhanced accuracy of editing without significant loss of efficiency at the desired target.
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