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Dermatology Online Journal

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Erythrodermic Darier disease associated with metastatic lung adenocarcinoma

  • Author(s): Hendricks, Aleksi J
  • Maarouf, Melody
  • Mills, Brandy W
  • Bertoch, Spencer T
  • Davis, Tracy L
  • Shi, Vivian Y
  • et al.

We present a patient with erythrodermic Darier disease occurring in temporal association with diagnosis of metastatic lung adenocarcinoma. The patient presented with eroded and crusted keratotic papules and plaques over greater than 90% body surface area with extensive secondary impetiginization. Given a longstanding history of pruritic eruption, this presentation represents a paraneoplastic flare of an underlying genodermatosis. Near total resolution was achieved with chemotherapy and topical corticosteroids.

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