Narayanam, Maruthi Kumar; Ma, Gaoyuan; Champagne, Pier Alexandre; Houk, Kendall N; Murphy, Jennifer M

doi:10.1002/anie.201707274

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Synthesis of [¹⁸ F]Fluoroarenes by Nucleophilic Radiofluorination of N-Arylsydnones.

2017

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https://doi.org/10.1002/anie.201707274

Abstract

A practical method for radiofluorination of anilines with [¹⁸ F]fluoride via N-arylsydnone intermediates is described. These precursors are stable, easy to handle and facilitate direct and regioselective ¹⁸ F-labeling to prepare [¹⁸ F]fluoroarenes. The value of this methodology is further highlighted by successful application to prepare an ¹⁸ F-labeled neuropeptide.

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UCLA

Synthesis of [18 F]Fluoroarenes by Nucleophilic Radiofluorination of N-Arylsydnones.

Published Web Location

Synthesis of [¹⁸ F]Fluoroarenes by Nucleophilic Radiofluorination of N-Arylsydnones.