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Building Bonds: Cancer Stem Cells Depend on Their Progeny to Drive Tumor Progression
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https://doi.org/10.1016/j.stem.2018.03.008Abstract
Little is currently known about how cancer stem-like cells (CSCs) interact with their more restricted progeny. In this issue of Cell Stem Cell, Wang et al. (2018) demonstrate a novel bidirectional signaling axis between CSCs and their progeny that is mediated by brain-derived neurotrophic factor and VGF accelerating glioma progression.
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