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Open Access Publications from the University of California

Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage.

  • Author(s): Wang, Hong
  • van Spyk, Elyse
  • Liu, Qiang
  • Geyfman, Mikhail
  • Salmans, Michael L
  • Kumar, Vivek
  • Ihler, Alexander
  • Li, Ning
  • Takahashi, Joseph S
  • Andersen, Bogi
  • et al.
Creative Commons Attribution 4.0 International Public License
Abstract

The epidermis is a highly regenerative barrier protecting organisms from environmental insults, including UV radiation, the main cause of skin cancer and skin aging. Here, we show that time-restricted feeding (RF) shifts the phase and alters the amplitude of the skin circadian clock and affects the expression of approximately 10% of the skin transcriptome. Furthermore, a large number of skin-expressed genes are acutely regulated by food intake. Although the circadian clock is required for daily rhythms in DNA synthesis in epidermal progenitor cells, RF-induced shifts in clock phase do not alter the phase of DNA synthesis. However, RF alters both diurnal sensitivity to UVB-induced DNA damage and expression of the key DNA repair gene, Xpa. Together, our findings indicate regulation of skin function by time of feeding and emphasize a link between circadian rhythm, food intake, and skin health.

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