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Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

  • Author(s): Amundadottir, Laufey
  • Kraft, Peter
  • Stolzenberg-Solomon, Rachael Z
  • Fuchs, Charles S
  • Petersen, Gloria M
  • Arslan, Alan A
  • Bueno-de-Mesquita, H Bas
  • Gross, Myron
  • Helzlsouer, Kathy
  • Jacobs, Eric J
  • LaCroix, Andrea
  • Zheng, Wei
  • Albanes, Demetrius
  • Bamlet, William
  • Berg, Christine D
  • Berrino, Franco
  • Bingham, Sheila
  • Buring, Julie E
  • Bracci, Paige M
  • Canzian, Federico
  • Clavel-Chapelon, Françoise
  • Clipp, Sandra
  • Cotterchio, Michelle
  • de Andrade, Mariza
  • Duell, Eric J
  • Fox, John W
  • Gallinger, Steven
  • Gaziano, J Michael
  • Giovannucci, Edward L
  • Goggins, Michael
  • González, Carlos A
  • Hallmans, Göran
  • Hankinson, Susan E
  • Hassan, Manal
  • Holly, Elizabeth A
  • Hunter, David J
  • Hutchinson, Amy
  • Jackson, Rebecca
  • Jacobs, Kevin B
  • Jenab, Mazda
  • Kaaks, Rudolf
  • Klein, Alison P
  • Kooperberg, Charles
  • Kurtz, Robert C
  • Li, Donghui
  • Lynch, Shannon M
  • Mandelson, Margaret
  • McWilliams, Robert R
  • Mendelsohn, Julie B
  • Michaud, Dominique S
  • Olson, Sara H
  • Overvad, Kim
  • Patel, Alpa V
  • Peeters, Petra HM
  • Rajkovic, Aleksandar
  • Riboli, Elio
  • Risch, Harvey A
  • Shu, Xiao-Ou
  • Thomas, Gilles
  • Tobias, Geoffrey S
  • Trichopoulos, Dimitrios
  • Van Den Eeden, Stephen K
  • Virtamo, Jarmo
  • Wactawski-Wende, Jean
  • Wolpin, Brian M
  • Yu, Herbert
  • Yu, Kai
  • Zeleniuch-Jacquotte, Anne
  • Chanock, Stephen J
  • Hartge, Patricia
  • Hoover, Robert N
  • et al.

Published Web Location

http://10.0.4.14/ng.429
No data is associated with this publication.
Abstract

We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

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