Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.
- Amundadottir, Laufey;
- Kraft, Peter;
- Stolzenberg-Solomon, Rachael Z;
- Fuchs, Charles S;
- Petersen, Gloria M;
- Arslan, Alan A;
- Bueno-de-Mesquita, H Bas;
- Gross, Myron;
- Helzlsouer, Kathy;
- Jacobs, Eric J;
- LaCroix, Andrea;
- Zheng, Wei;
- Albanes, Demetrius;
- Bamlet, William;
- Berg, Christine D;
- Berrino, Franco;
- Bingham, Sheila;
- Buring, Julie E;
- Bracci, Paige M;
- Canzian, Federico;
- Clavel-Chapelon, Françoise;
- Clipp, Sandra;
- Cotterchio, Michelle;
- de Andrade, Mariza;
- Duell, Eric J;
- Fox, John W;
- Gallinger, Steven;
- Gaziano, J Michael;
- Giovannucci, Edward L;
- Goggins, Michael;
- González, Carlos A;
- Hallmans, Göran;
- Hankinson, Susan E;
- Hassan, Manal;
- Holly, Elizabeth A;
- Hunter, David J;
- Hutchinson, Amy;
- Jackson, Rebecca;
- Jacobs, Kevin B;
- Jenab, Mazda;
- Kaaks, Rudolf;
- Klein, Alison P;
- Kooperberg, Charles;
- Kurtz, Robert C;
- Li, Donghui;
- Lynch, Shannon M;
- Mandelson, Margaret;
- McWilliams, Robert R;
- Mendelsohn, Julie B;
- Michaud, Dominique S;
- Olson, Sara H;
- Overvad, Kim;
- Patel, Alpa V;
- Peeters, Petra HM;
- Rajkovic, Aleksandar;
- Riboli, Elio;
- Risch, Harvey A;
- Shu, Xiao-Ou;
- Thomas, Gilles;
- Tobias, Geoffrey S;
- Trichopoulos, Dimitrios;
- Van Den Eeden, Stephen K;
- Virtamo, Jarmo;
- Wactawski-Wende, Jean;
- Wolpin, Brian M;
- Yu, Herbert;
- Yu, Kai;
- Zeleniuch-Jacquotte, Anne;
- Chanock, Stephen J;
- Hartge, Patricia;
- Hoover, Robert N
- et al.
Abstract
We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.
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