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Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

  • Author(s): Amundadottir, Laufey;
  • Kraft, Peter;
  • Stolzenberg-Solomon, Rachael Z;
  • Fuchs, Charles S;
  • Petersen, Gloria M;
  • Arslan, Alan A;
  • Bueno-de-Mesquita, H Bas;
  • Gross, Myron;
  • Helzlsouer, Kathy;
  • Jacobs, Eric J;
  • LaCroix, Andrea;
  • Zheng, Wei;
  • Albanes, Demetrius;
  • Bamlet, William;
  • Berg, Christine D;
  • Berrino, Franco;
  • Bingham, Sheila;
  • Buring, Julie E;
  • Bracci, Paige M;
  • Canzian, Federico;
  • Clavel-Chapelon, Françoise;
  • Clipp, Sandra;
  • Cotterchio, Michelle;
  • de Andrade, Mariza;
  • Duell, Eric J;
  • Fox, John W;
  • Gallinger, Steven;
  • Gaziano, J Michael;
  • Giovannucci, Edward L;
  • Goggins, Michael;
  • González, Carlos A;
  • Hallmans, Göran;
  • Hankinson, Susan E;
  • Hassan, Manal;
  • Holly, Elizabeth A;
  • Hunter, David J;
  • Hutchinson, Amy;
  • Jackson, Rebecca;
  • Jacobs, Kevin B;
  • Jenab, Mazda;
  • Kaaks, Rudolf;
  • Klein, Alison P;
  • Kooperberg, Charles;
  • Kurtz, Robert C;
  • Li, Donghui;
  • Lynch, Shannon M;
  • Mandelson, Margaret;
  • McWilliams, Robert R;
  • Mendelsohn, Julie B;
  • Michaud, Dominique S;
  • Olson, Sara H;
  • Overvad, Kim;
  • Patel, Alpa V;
  • Peeters, Petra HM;
  • Rajkovic, Aleksandar;
  • Riboli, Elio;
  • Risch, Harvey A;
  • Shu, Xiao-Ou;
  • Thomas, Gilles;
  • Tobias, Geoffrey S;
  • Trichopoulos, Dimitrios;
  • Van Den Eeden, Stephen K;
  • Virtamo, Jarmo;
  • Wactawski-Wende, Jean;
  • Wolpin, Brian M;
  • Yu, Herbert;
  • Yu, Kai;
  • Zeleniuch-Jacquotte, Anne;
  • Chanock, Stephen J;
  • Hartge, Patricia;
  • Hoover, Robert N
  • et al.

Published Web Location
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We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

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