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Open Access Publications from the University of California

Apparent darkening of scalp hair related to pili multigemini Following dabrafenib and trametinib

  • Author(s): Avila, Christina
  • Hoffman, Kalyn
  • Milani-Nejad, Nima
  • Pootrakul, Llana
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license

The combination of dabrafenib and trametinib is an important immunotherapy option for patients with BRAF V600 mutation-positive melanoma. This regimen has been reported to cause cutaneous eruptions. However, hair dysmorphology is not a reported side effect to these or any other medications to date. Herein, we highlight a case of pili multigemini formation in a patient with stage IV melanoma receiving treatment with dabrafenib and trametinib and the corresponding clinical findings.

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