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Acrokeratoelastoidosis

  • Author(s): Mu, Euphemia W
  • Mir, Adnan
  • Meehan, Shane A
  • Nguyen, Nathalie
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license
Abstract

Acrokeratoelastoidosis is a rare palmoplantar keratoderma. We report the case of a 32-year old man with multiple keratotic papules and plaques on the peripheral margins of his hands and feet. Histopathologic evaluation showed compact orthokeratosis; Verhoeff van Gieson stain showed thin and fragmented elastic fibers. The differential diagnosis includes focal acral hyperkeratosis, which has a similar presentation but with normal elastic fibers. Treatment of acrokeratoelastoidosis is often disappointing, with minimal response to topical glucocorticoids, keratolytics, retinoids, cryotherapy, and lasers.

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