The role of oxidized phospholipids in bleomycin-induced pulmonary fibrosis
Oxidized phospholipids (OxPLs), which are generated with the presence of oxidative stress, are proven to be pro-inflammatory and pro-atherogenic, but their roles in bleomycin-induced pulmonary fibrosis remains unknown. In this study, I show that bleomycin treatment induces expression of fibrogenic and inflammatory genes and accumulation of OxPL in mouse alveolar macrophages. Accumulation of OxPL occurs in prior to elevation of inflammatory and fibrotic genes, which suggests that OxPL might have to be first generated to promote fibrogenic response in response to bleomycin in alveolar macrophages. I also demonstrate OxPAPC induces expression of fibrogenic and inflammatory genes in mouse alveolar macrophages, which further confirms a potential fibrogenic role of OxPL. My study might provide a new direction for therapies that aims to attenuate bleomycin-induced pulmonary fibrosis during chemotherapy.