Fibromodulin and Its Derivative Reduce Scars in Adult Porcine Models
Background: Fibromodulin (FMOD) has been demonstrated to decrease scarring in mouse models. We developed an FMOD-based peptide, F06-C40, which has similar effect as FMOD while being more efficient and less costly to produce. In this study, the effect of FMOD and F06-C40 on scars was tested in porcine models for future preclinical studies.
Methods: Full-thickness incisional wounds were generated on the dorsum of Yorkshire pigs or red Duroc pigs to simulate human normal or hypertrophic scarring. FMOD, F06-C40, or PBS was injected intradermally around the wound edge. At 8 weeks post-injury, scar formation was evaluated by gross appearance, histological analysis, and tensile strength.
Results: FMOD and F06-C40 peptide significantly reduced scar formation and increased tensile strength in both Yorkshire pig and red Duroc pig models.
Conclusion: The results indicate F06-C40 has the potential to be developed as a novel therapeutic for improving wound healing in normal and hypertrophic scarring patients.