Skip to main content
Open Access Publications from the University of California


UCLA Previously Published Works bannerUCLA

Regression of murine lung tumors by the let-7 microRNA.

  • Author(s): Trang, P;
  • Medina, PP;
  • Wiggins, JF;
  • Ruffino, L;
  • Kelnar, K;
  • Omotola, M;
  • Homer, R;
  • Brown, D;
  • Bader, AG;
  • Weidhaas, JB;
  • Slack, FJ
  • et al.

MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human diseases, including cancer. Here, we show that loss of let-7 function enhances lung tumor formation in vivo, strongly supporting the hypothesis that let-7 is a tumor suppressor. Moreover, we report that exogenous delivery of let-7 to established tumors in mouse models of non-small-cell lung cancer (NSCLC) significantly reduces the tumor burden. These results demonstrate the therapeutic potential of let-7 in NSCLC and point to miRNA replacement therapy as a promising approach in cancer treatment.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View