Skip to main content
Stereoselective Synthesis of γ‑Lactams from Imines and Cyanosuccinic Anhydrides
Published Web Location
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874237/pdf/nihms528048.pdfNo data is associated with this publication.
Abstract
A reaction between imines and anhydrides has been developed with chiral disubstituted anhydrides and chiral imines. The synthesis of highly substituted γ-lactams with three stereogenic centers, including one quaternary center, proceeds at room temperature in high yield and with high diastereoselectivity in most cases. Enantiomerically pure alkyl-substituted anhydrides proceed with no epimerization, thus providing access to enantiomerically pure penta-substituted lactam products.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.