Skip to main content
Open Access Publications from the University of California

Stereoselective synthesis of γ-lactams from imines and cyanosuccinic anhydrides

  • Author(s): Tan, DQ
  • Younai, A
  • Pattawong, O
  • Fettinger, JC
  • Cheong, PHY
  • Shaw, JT
  • et al.

Published Web Location
No data is associated with this publication.

A reaction between imines and anhydrides has been developed with chiral disubstituted anhydrides and chiral imines. The synthesis of highly substituted γ-lactams with three stereogenic centers, including one quaternary center, proceeds at room temperature in high yield and with high diastereoselectivity in most cases. Enantiomerically pure alkyl-substituted anhydrides proceed with no epimerization, thus providing access to enantiomerically pure penta-substituted lactam products. © 2013 American Chemical Society.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item