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The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells
- Bertin, Samuel;
- Aoki-Nonaka, Yukari;
- de Jong, Petrus Rudolf;
- Nohara, Lilian L;
- Xu, Hongjian;
- Stanwood, Shawna R;
- Srikanth, Sonal;
- Lee, Jihyung;
- To, Keith;
- Abramson, Lior;
- Yu, Timothy;
- Han, Tiffany;
- Touma, Ranim;
- Li, Xiangli;
- González-Navajas, José M;
- Herdman, Scott;
- Corr, Maripat;
- Fu, Guo;
- Dong, Hui;
- Gwack, Yousang;
- Franco, Alessandra;
- Jefferies, Wilfred A;
- Raz, Eyal
Published Web Location
https://doi.org/10.1038/ni.3009Abstract
The membrane channel TRPV1 is well studied as a pain receptor, but its function beyond sensory neurons remains unclear. Raz and colleagues demonstrate that TRPV1 is also a non–store-operated calcium channel on CD4+ T cells with an important function in cell activation.
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