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The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells
- Bertin, Samuel;
- Aoki-Nonaka, Yukari;
- de Jong, Petrus Rudolf;
- Nohara, Lilian L;
- Xu, Hongjian;
- Stanwood, Shawna R;
- Srikanth, Sonal;
- Lee, Jihyung;
- To, Keith;
- Abramson, Lior;
- Yu, Timothy;
- Han, Tiffany;
- Touma, Ranim;
- Li, Xiangli;
- González-Navajas, José M;
- Herdman, Scott;
- Corr, Maripat;
- Fu, Guo;
- Dong, Hui;
- Gwack, Yousang;
- Franco, Alessandra;
- Jefferies, Wilfred A;
- Raz, Eyal
- et al.
Published Web Location
https://doi.org/10.1038/ni.3009Abstract
TRPV1 is a Ca(2+)-permeable channel studied mostly as a pain receptor in sensory neurons. However, its role in other cell types is poorly understood. Here we found that TRPV1 was functionally expressed in CD4(+) T cells, where it acted as a non-store-operated Ca(2+) channel and contributed to T cell antigen receptor (TCR)-induced Ca(2+) influx, TCR signaling and T cell activation. In models of T cell-mediated colitis, TRPV1 promoted colitogenic T cell responses and intestinal inflammation. Furthermore, genetic and pharmacological inhibition of TRPV1 in human CD4(+) T cells recapitulated the phenotype of mouse Trpv1(-/-) CD4(+) T cells. Our findings suggest that inhibition of TRPV1 could represent a new therapeutic strategy for restraining proinflammatory T cell responses.
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