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Open Access Publications from the University of California

Keratoacanthoma-like nodules as first manifestation of metastatic epithelioid trophoblastic tumor

  • Author(s): Gil, F
  • Elvas, L
  • Raposo, S
  • Carvalho, T
  • Gil, J
  • Cardoso, JC
  • Fernandes, B
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license

Cutaneous metastases are rarely the initial manifestation of a previously undiagnosed malignancy and keratoacanthoma-like lesions are a notoriously unusual presentation pattern of cutaneous dissemination of a primary tumor. Herein, we report a 40-year-old woman presenting to our dermatology department with multiple keratoacanthoma-like scalp nodules. Subsequent investigation determined it to be the first manifestation of a disseminated endometrial epithelioid trophoblastic tumor, eventually causing the patient's death. Epithelioid trophoblastic tumor, a rare form of gestational trophoblastic disease, is a recently described neoplasm whose cutaneous metastasis has not been previously reported in the literature.

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