Recognizing the long-standing and emerging challenges to global health, the University of California Global Health Institute will create multi-campus, transdisciplinary Centers of Expertise to address these challenges through a novel problem-based and action-oriented approach. By integrating and leveraging the diverse intellectual capacity of faculty on the ten UC campuses, this groundbreaking University-wide initiative will focus on producing leaders and practitioners of global health, conducting innovative research, and developing international partnerships to improve the health of vulnerable people and communities in California and world-wide. The Institute will take advantage of cutting-edge technology to enable teaching and research and to connect faculty, researchers, students and partners around the world.