Skip to main content
eScholarship
Open Access Publications from the University of California

Department of Medicine

Open Access Policy Deposits bannerUCLA

Open Access Policy Deposits

This series is automatically populated with publications deposited by Department of Medicine researchers in accordance with the University of California’s open access policies. For more information see Open Access Policy Deposits and the UC Publication Management System.


Cover page of ‘I have a child i need to live for’: a qualitative study of parenthood and the TB experience in South Africa

‘I have a child i need to live for’: a qualitative study of parenthood and the TB experience in South Africa

(2026)

Existing research highlights TB's economic and social stigma burdens and impacts behavior in households, but virtually unexplored is the dynamics of TB and parenthood. This qualitative study examines the interplay between TB diagnosis and treatment, and parenting experiences, focusing on the intersections of individual agency, societal expectations, and access to resources. From March 2021 to January 2022, we conducted in-depth interviews with 98 TB patients in Buffalo City, South Africa, including 44 mothers and 54 fathers. Guided by the Network-Individual-Resource (NIR) model, we applied layered coding, memoing, and causal mapping to analyze experiences through the lens of agency and societal expectations. Mothers reported primary caregiving responsibilities, drawing motivation from their children, and relying on multigenerational family support for childcare and treatment-adherence. Children frequently provided emotional and practical care, such as cooking and medication reminders. Fathers more often distanced themselves to protect families from infection, faced isolation, and struggled to fulfill provider roles due to job loss. Extended family support for fathers was limited, with financial pressures exacerbating treatment challenges. These results illustrate how gender norms and resources structure the TB experience. Strengthening maternal caregiving networks and reimagining fatherhood beyond economic provision can foster better adherence and more equitable health outcomes.

Unpacking “High-Risk”: A Latent Class Analysis of Sexual Partnership Patterns and HIV Transmission Risk Among Gay, Bisexual, and Other Men Who Have Sex With Men in Perú

(2026)

BACKGROUND: Gay, bisexual, and other men who have sex with men (GBMSM) are often considered a homogenous "high-risk" group. We aimed to differentiate subgroups based on participants' last sexual partner and explore associations with HIV transmission risk factors. SETTING: We utilized cross-sectional data (06/2022 to 03/2023) from "high-risk" GBMSM in Lima, Perú. METHODS: Participants included cisgender men and gender nonconforming adults assigned male at birth reporting condomless anal sex with ≥1 serodiscordant or unknown serostatus cisgender man or transgender woman in the past 6 months. Latent class analysis was performed using the last sexual partner characteristics, including partner type, sexual role, and condomless anal sex position. Multinomial logistic regression examined HIV risk factors associated with latent classes, including drug use, transactional sex, sexually transmitted infection diagnosis, sexual identity, hazardous alcohol use, and number of anonymous partners. RESULTS: From 2119 participants (47.1% living with HIV), 5 latent classes were identified: "pasivo partner" (26.1%); " one-time activo partner" (20.2%); " recurring activo partner" (16.6%); " one-time moderno partner" (13.3%); and "recurring moderno partner" (23.8%). Class memberships were each associated with different groupings of HIV transmission risk factors. Certain moderno partner classes were associated with substance use and larger anonymous sexual networks, particularly among GBMSM not living with HIV, compared with the "pasivo partner" class. CONCLUSIONS: Our findings demonstrate that GBMSM in Lima represent a behaviorally diverse population whose HIV risk is shaped by sexual roles, partnership types, and network structures. Culturally informed prevention strategies that incorporate these dynamics-such as role-specific partner-notification methods-are essential to more effectively address HIV transmission in the region.

Cover page of What Dose of Methamphetamine Do Regular Consumers Use Daily? Estimating Oral Amphetamine Milligram Equivalents

What Dose of Methamphetamine Do Regular Consumers Use Daily? Estimating Oral Amphetamine Milligram Equivalents

(2026)

OBJECTIVES: The purity, accessibility, and affordability of illicit methamphetamine have increased in recent decades, which has been linked to rising rates of methamphetamine-involved overdoses, psychosis, cardiovascular events, and other health consequences. Nevertheless, information about the quantity of methamphetamine used by regular consumers has been limited, despite the potential clinical utility of exposure quantification. METHODS: From August 2024 to April 2026, self-reported daily methamphetamine consumption was assessed among n = 94 individuals in Los Angeles County. Methamphetamine samples (n = 256) were analyzed for purity using liquid chromatography-mass spectrometry. Bioavailability by route of administration and stimulant equivalency were obtained from the literature. A simulation model leveraging bootstrapping with 1,000,000 draws was used to estimate oral amphetamine milligram equivalents (AME). RESULTS: The average reported methamphetamine consumption was 1.09 g daily (95% prediction interval: 0.07-4.00). Average purity was 84.52% (95% PI: 14.90%-100.00%). Given estimated average bioavailability of 66.41% (95% PI: 39.35%-85.24%), the average consumer used an estimated 1432.54 AME daily (95% PI: 35.74-6973.05). CONCLUSIONS: We estimate that consumers of methamphetamine in Los Angeles use an average daily stimulant dose (nearly 1500 oral AME) about 25-fold higher than the maximum typical recommended clinical dose of mixed amphetamine salts (60 mg). This may help contextualize why prescription stimulant treatment trials using substantially lower doses have shown limited efficacy. Given this high dose, these findings shed light on the rising incidence of methamphetamine-related sequelae, such as psychosis, cardiovascular complications, and sudden death. Although exposure quantification is commonplace for alcohol and tobacco use disorders, uncertainties in illicit drug markets have complicated this practice for most illicit drugs. This study supports leveraging emerging information from drug checking programs so that clinicians can approximate exposure quantification.

Cover page of Dashboard-Directed Intervention to Improve Guideline-Directed Heart Failure Therapy for Veterans

Dashboard-Directed Intervention to Improve Guideline-Directed Heart Failure Therapy for Veterans

(2026)

BACKGROUND: Significant gaps in guideline-directed medical therapy (GDMT) persist in patients with heart failure (HF) with reduced ejection fraction (HFrEF). Although population health dashboards can identify these gaps, sustainable workflows integrating them into routine practice remain largely underutilized. OBJECTIVES: This study aimed to evaluate the implementation and outcomes of a dashboard-based intervention in a novel clinical-educational hybrid model aimed to improve GDMT use. METHODS: From July 2024 to June 2025, a weekly, half-day HF Dashboard Population Health Clinic was implemented at a single Veterans Affairs center. A supervised team of cardiology fellows and nurse practitioners performed medical record reviews of patients with gaps in GDMT identified on the Veterans Affairs HF Dashboard, with a focus on underutilization of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in HFrEF patients. Clinicians executed targeted telehealth interventions, initiated therapies, and coordinated follow-up. Outcomes were measured via an optimization score for each GDMT component (0 = none, 1 = low dose, 2 = target dose). RESULTS: Over 1 year, 163 patients received the Dashboard Clinic intervention; 128 (78.5%) had HFrEF and 150 (92.0%) were not receiving SGLT2i therapy. In 79 patients (48.5%), GDMT was initiated via telephone or recommended for initiation. In patients who qualified for GDMT optimization (N = 107), the composite optimization score increased from 2.10 (SD = 1.88) before intervention to 2.81 (SD = 2.17) after intervention (P = 0.018), and the OS of SGLT2i therapy increased from 0.40 (SD = 0.80) to 0.74 (SD = 0.97) (P = 0.013). CONCLUSIONS: The Dashboard Clinic is a viable and potentially effective intervention for GDMT optimization, providing a scalable blueprint for dashboard-directed care.

Cover page of Long COVID sequelae in heart transplant recipients

Long COVID sequelae in heart transplant recipients

(2026)

Post acute sequelae of SARS-CoV-2 infection (also known as Long COVID) have been defined as symptoms that persist after 3 months from initial acute episode of COVID-19. While the pathophysiology and mechanisms that cause Long COVID are hypothesized as secondary to persistent inflammation and immune dysregulation, the burden of this disease remains difficult to estimate due to varied symptomatology. Solid-organ transplant recipients in particular remain a vulnerable population that has been disproportionately affected by the COVID-19 pandemic, and the impact of Long COVID among orthotopic heart transplant recipients (OHTRs)-a patient population on chronic immunosuppressive therapy-remains incompletely characterized. We sought to evaluate patient-reported Long COVID symptoms between OHTRs compared to patients with baseline cardiomyopathy. We conducted a prospective survey-based study of adult OHTRs and cardiomyopathy control patients with documented SARS-CoV-2 infection. Participants completed telephone surveys, which included questionnaires of symptoms, quality of life (QOL), and mental health assessment. Between-group differences were evaluated using multivariable models adjusting for baseline characteristics. Our results show that the prevalence of Long COVID symptoms did not significantly differ between OHTRs and patients with cardiomyopathy. Dyspnea was reported more frequently in the non-OHTR group; however, this association was attenuated after adjusting for a higher burden of underlying pulmonary disease. No evidence of increased overall symptom burden was observed among OHTRs. In this first comparative analysis of Long COVID among OHTRs and control cardiomyopathy patients, OHTRs demonstrated no increase in symptom burden and may experience fewer persistent symptoms.

Cover page of Improving Medication Reconciliation at Discharge: A Cross-Sectional Survey.

Improving Medication Reconciliation at Discharge: A Cross-Sectional Survey.

(2026)

Background

Medication discrepancies remain a persistent patient safety concern despite decades of quality improvement efforts. Research indicates that about half of hospitalized adults experience at least one such discrepancy after discharge, often stemming from unclear clinician roles and poor communication among nurses, physicians, and pharmacists. Understanding nurses' perspectives is critical to designing interventions that will improve medication reconciliation and enhance patient safety at discharge.

Purpose

This study aimed to explore RNs' perspectives of medication reconciliation during hospital discharge, focusing on barriers, communication patterns, and opportunities for system improvement.

Methods

A cross-sectional survey was administered to nursing staff across medical telemetry, cardiac observation, short-stay, and general observation units at a large quaternary academic teaching hospital between March 21 and April 30, 2022. The survey assessed nurses' comfort with patient education, perceived role responsibilities, and collaboration with other disciplines. Quantitative responses were summarized descriptively, and open-ended responses were analyzed using inductive content analysis to identify recurring themes.

Results

Of the 217 nurses invited to participate, 108 completed the survey. Most nurses reported high comfort levels in using teach-back methods (93.5%) and reviewing reconciled medication lists with patients (87%). Responsibility for medication-related discharge tasks was most often viewed as shared, including medication teaching and schedule review as well as communicating medication changes made during hospitalization. Collaboration with pharmacists received the most favorable evaluations, with a majority (60.1%) rating it good or excellent. In contrast, a majority rated as average or worse collaboration with physicians (54.6%), case managers (68.5%), and social workers (63.9%). Free-text responses to open-ended items added further insights.

Conclusions

The study findings indicate that while nurses generally feel confident about their ability to provide patient education, their ability to deliver accurate medication information is hindered by incomplete or inconsistent documentation, role ambiguity, and lapses in interdisciplinary communication. Addressing these issues will require targeted educational interventions, improved interprofessional collaboration, and expanded pharmacy integration. Embedding technological tools such as automated notifications into discharge planning workflows could further improve medication reconciliation and ensure safe care transitions. To achieve these goals, nurses must have accurate medication information, role clarity, and integrated interdisciplinary support.

Cover page of NCCN Guidelines® Insights: Survivorship, Version 3.2026.

NCCN Guidelines® Insights: Survivorship, Version 3.2026.

(2026)

The NCCN Guidelines for Survivorship offer guidance for health care providers who care for survivors of adult-onset cancer. These guidelines include screening, evaluation, and treatment recommendations for common physical and psychosocial problems resulting from cancer and its treatment and provide a framework for care coordination. They also present guidance for helping cancer survivors to enhance their wellness and maintain a healthy lifestyle. This article summarizes the panel's current recommendations and recent updates regarding anxiety, depression, distress, and trauma in cancer survivors.