- Le, Hoan N;
- Tran, Vuvi G;
- Vu, Trang TT;
- Gras, Emmanuelle;
- Le, Vien TM;
- Pinheiro, Marcos Gabriel;
- Aguiar-Alves, Fábio;
- Schneider-Smith, Erika;
- Carter, Henry Clay;
- Sellman, Bret R;
- Stover, C Kendall;
- DiGiandomenico, Antonio;
- Diep, Binh An
Pseudomonas aeruginosa is a challenge for clinicians due to increasing drug resistance and dwindling treatment options. We report on the activity of MEDI3902, an antibody targeting type 3 secretion protein PcrV and Psl exopolysaccharide, in rabbit bloodstream and lung infection models. MEDI3902 prophylaxis or treatment was protective in both acute models and exhibited enhanced activity when combined with a subtherapeutic dose of meropenem. These findings further support MEDI3902 for the prevention or treatment of serious P. aeruginosa infections.
