Here we show that brain seizures can be effectively suppressed through random modulation of the brain medium. We use an established mesoscale cortical model in the form of a system of coupled stochastic partial differential equations. We show that by temporal and spatial randomization of parameters governing the firing rates of the excitatory and inhibitory neuron populations, seizure waves can be significantly suppressed. We find that the attenuation is the most effective when applied to the mean threshold potential. The proposed technique can serve as a non-invasive paradigm to mitigate epileptic seizures without knowing the location of the epileptic foci.

Optical methods for imaging and stimulation of biological events based on the use of visible light are limited to the superficial layers of tissue due to the significant absorption and scattering of light. Here, we demonstrate the design and implementation of passive micro-structured lightbulbs (MLBs) containing bright-emitting lanthanide-doped upconverting nanoparticles (UCNPs) for light delivery deep into the tissue. The MLBs are realized as cylindrical pillars made of Parylene C polymer that can be implanted deep into the tissue. The encapsulated UCNPs absorb near-infrared (NIR) light at λ = 980 nm, which undergoes much less absorption than the blue light in the brain tissue, and then locally emit blue light (¹G₄→³H₆ and ¹D₂→³F₄ transitions) that can be used for optogenetic excitation of neurons in the brain. The ³H₄→³H₆ transition will result in the emission of higher energy NIR photons at λ = 800 nm that can be used for imaging and tracking MLBs through thick tissue.